Pinta ship in oswego ny12/12/2023 ![]() The owner of La Pinta was Cristóbal Quintero. The New World was first sighted by Rodrigo de Triana aboard La Pinta on 12 October 1492.
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Scrivener 3 release date for windows12/12/2023 ![]() mobi), Meta data, Inspector Comments and Footnotes, Collections, Multimarkdown, Multiple Project Notes, Final Draft import and export, Composition mode background image, Custom Binder icons, Syncing with iOS and cloud, etc. Scrivener 1 for Windows was only ever supposed to match Mac Scrivener 1.5.4, but soon incorporated many Scrivener 2 Mac features (that Mac users paid an upgrade fee for). For version 1 we spent around a year in beta I still have the nightmares - don't ever try and build your own rich text engine from scratch debugging that thing is like opening Pandora's box. I believe Scrivener for Windows history speaks for itself. ![]() Intrepid users can always download the beta of Scrivener 3 after all and the beta has been robust and stable for at least six months or so now. Often, that last 5%-10% of development tweaking and fixing is hard to justify as it takes an inordinate amount of extra time especially when many organisations just push it out and fix it later, but we don't see the need to frustrate our audience that way. We do this because we genuinely care about our audience, and our software. We just don't release half-baked software, but strive for the best it can reasonably be with a high utility yield. Scrivener for Mac has never stopped moving - ever! Keith once compared my role akin to Sisyphusįirst and foremost, we are all determined to get it right. Thankfully we are very close now, so I wanted to personally give some insight into the hurdles and challenges we have had to overcome. We initially slated “some time in 2018” for release, but later revised that to “by the end of Q2 2019”, and we're not going to make that either. Heck, if I were a Scrivener Windows user without the perspective and insight I have, I'd be mulling over some verbal eggs to lob across the fence in frustration right now too. Two months ago, similar frustrations and questions were thumping around inside my head. I understand that some Windows users are getting more and more frustrated, wondering if the release of Scrivener 3 for Windows is ever going to happen! I get it. Our Windows development team provides an insight into progress. Scrivener 3.0 for Windows - from the horse's mouth Scrivener is the go-to app for writers of all kinds, used every day by best-selling novelists, screenwriters, essayists, students, academics, lawyers, journalists, translators and more. ![]() Do not ask for pirated links to Scrivener or any other software. It’s fine to disagree, but name-calling and personal attacks will not be tolerated and may result in bans.ģ. While discussions about Scrivener alternatives or complementary programs are welcome, posts that exclusively promote other software or writing resources will be removed as spam at moderator discretion.Ģ. Contact L&L L&L Official Forum Click Here for the S3 Windows Beta Subreddit Rules:ġ. Users wishing to request tech support, report bugs, or give feedback should contact Literature & Latte directly through one of the below channels. Members on this sub will do their best to help when possible, but ultimately have limited knowledge and no control over the program. This sub is not officially affiliated with Scrivener. ![]() Calculus teeth12/12/2023 ![]() ![]() There are several ways to get rid of it before it becomes serious. ![]() This can cause tooth decay and gum disease. This means that the bacteria found in plaque becomes trapped between your teeth, where it decays into tarter and sticks to your teeth for good. RELATED: HOW TO GET RID OF PLAQUE BUILDUP ON TEETH What is Tartar? The more sugar you eat, the more damaging plaque will be on your teeth!Īs long as you’re brushing your teeth twice a day for two minutes, temporary plaque buildup won’t cause long-lasting damage. Bacteria in plaque convert sugar into acid, which causes tooth decay and cavities. Plaque forms when you eat or drink anything with carbohydrates (sugar). Plaque forms constantly, meaning it’s not abnormal to see or feel it during the middle of your day. When know plaque is normal, but should you have plaque on your teeth every day? You’ll know you have plaque buildup if you have teeth sweaters, your gums bleed after brushing or flossing, or you have consistent bad breath. In as little as 24-72 hours, it turns into tartar (also known as calculus). It is normal, but if it isn’t removed by brushing, flossing, and regular visits to the dental hygienist, it can lead to cavities. Plaque is a sticky film of bacteria that builds up on your teeth. By having an oral hygiene routine and by seeing your dentist for professional cleanings, you can keep your smile healthy for years! What is Plaque? And according to the CDC, 26% of American adults have untreated tooth decay. If you don’t remove plaque and tartar, they can cause tooth decay or gum disease. The difference between plaque and tartar is that tartar has become mineralized over time, making it more difficult for you to remove it with regular brushing or flossing at home. Both contain a mixture of living and dead bacteria and food particles such as sugar (or “ dental plaque “). Plaque and tartar are remnants of oral plaque that adhere to the tooth surface after eating. RELATED: HOW MUCH DOES A TEETH CLEANING COST? Plaque vs. This is exactly why you should know the difference. ![]() But can you remove plaque and tartar from home? The answer is: sometimes- but it’s more difficult to remove tartar than plaque. If you want to prevent plaque from turning into tartar, it’s important to do what you can on your own. However, one is more serious than the other. By ensuring you attend all your regular dental appointments, you can get rid of the excess plaque and tartar so your dentist and dental hygienist can continue to provide you with great care for a beautiful white smile.There’s not a huge difference when it comes to plaque vs. The procedure gives your dental professional a better look at your oral health. If it's been a while since you last visited a dentist, a full mouth debridement may help get you back on track.
Amadeus pro for windows12/12/2023 ![]() ![]() ![]() “Smart split” is simple but it works & outputs splits easily I'm also not taking price into consideration in these cases because they're mostly lower cost.ĭisplays stereo files as one waveform-no L/R editing/playback I'm most concerned with: ease of mouse zooming/highlighting & generally zipping around a file, playing/editing L/R channels of a stereo file independently, running 3rd party FX, splitting recorded sections into regions/labels/markers/etc, and outputting those splits as separate files. I only tested these with functions that I use most often (ie: these won't be the same for everyone) but I'm sure some of these have great features I don't know about. Another option might be to see what game developers are using (maybe look around on Steam), options which might look more "game-oriented," but have the features you need.īut generally speaking, it is the case that simple, easy-to-use software doesn't have a good business model, so a lot of it has died out.įirst run on some of the rec'd apps. That's what happens in a lot of professional environments. In other cases, using an emulator for an old OS can work, or sticking with an old machine that consistently runs your production software. OS changes, security measures, language changes, adware, business models other than ad/spyware dying out, "mobile-first" being the only viable option, these all add up to degrade the experience of what used to be simpler, more effective, more direct ways of doing things for professional-quality desktop programs.įor workable solutions, in some cases, migrating to browser-based versions of older software can work, but the restrictions of browsers can be problematic. ![]() I'm not sure this is the correct way to view things software for working professionals in a number of fields has gotten measurably worse over time, due to business changes and the shifts in computing platforms making stability hard to come by. ***I should add that, on a daily basis, I use SoundStudio 4 ( ) which is fine for simple, one-off waveform editing but not suited to larger projects involving regions and batch processing. On the other end of the spectrum are the freebie/low cost apps like Audacity and WavePad (and many others) but I don't know if these will have the functions I need and I haven't bothered to find out because I'm not sure if I trust these with an entire sample library production.Īre simple audio editors/batch processors a thing of the past? What apps are people using? I don't need a BMW, just a reliable Toyota. I've seen others like Samplitude, FL Studio, RX8, etc etc but these are expensive and, frankly, too complicated and overloaded with features for the simple type of editing I do. I briefly tried Pro Tools First and PreSonus Studio One-thinking these would be simpler, paired-down versions of their bloatware-but the UIs were a learning curve, simple functions not obvious, and I think I encountered the same shortcomings as with Triumph. For waveform editing, you need quick, direct mouse control on a waveform for zooming, shuttling, selecting, dragging, fading etc etc and Triumph had weird key combinations and odd mouse settings for doing this. I bought Triumph a couple years ago but it turned out to be surprisingly non-user-friendly. Among other things, I make sample libraries which involves a lot of detailed waveform work as well as batch processing. I'm still using an older version of Sound Forge (buggy as hell) on an old Mac because I honestly haven't found a good replacement. everything in a new thread (with prices): Īs someone who started audio editing way back with SoundEdit16 and Sound Forge, I'm having a really hard time finding similar software that can run on newer OS X versions. Cheers for all the suggestions/advice adapt or die. *UPDATE* This post kinda blew up so there are a ton of good recs I'm trying to follow up on now. ![]() Alarm clock online12/12/2023 ![]() ![]() Like some other web apps, it synchronises with your system time and lets you set any time to play the alarm tone. Visit websiteĭolly Clock is a good looking website with all the possible functionalities that you might need on an online alarm clock website. If you are done with these two options, you can click the Start alarm button. On the other hand, you can choose an alarm sound. Now, you can write down a small title or message to recognise the alarm. After that, click the Go to the alarm settings button. As it uses AM/PM format, you won’t have any problem setting up the time. After visiting the Set Alarm Clock website, you need to set the time first. Like any other website, it helps you set the alarm at any time. It is another simple online alarm clock website that lets you set the alarm at any time. Following that, you need to select a time and alarm tone. To get started, head to the website, and click the CREATE NEW ALARM button. By default, it used 24 hours time format, but you can use the AM/PM option as well. Another handy function is that you can place an alarm on ChromeCast. No matter what time you have set, you can choose audio from YouTube to be played as the alarm tone. This is possible to set music from YouTube as your alarm tone. It is probably the unique website which lets you set alarms, but it specialises in a different aspect. As it allows you to set multiple alarms, the title will help you recognise an alarm in case you want to delete it. To set the alarm on this website, you need to click the Set Alarm button, and set the time, sound, and title. V Clock synchronises the time zone automatically so that you do not need to set the original time. If you like, you can choose something from that list, or you can create your alarm manually. After visiting this website, you can find some preset alarms that other users have set recently. The speciality of V Clock is that you can set multiple alarms, which is unavailable on most of the websites mentioned on this list. The last but not the least thing is that you need to set time in 24-hour format. As you are about to wake up after sleep or nap, this is recommended to go with the dark mode for not getting any eye strain. The good news is that it comes with dark mode, which is quite an eye-friendly in the night time. Talking about the user interface, Kuku Klok has a basic UI that might attract you. Like a standard online alarm website, it allows you to set the desired alarm sound. Kuku Klok is another online alarm website that you can use to set the alarm at a particular time. Like the Google website, you can find a timer as well as a stopwatch on the Online Alarm Clock website. ![]() Another useful feature is that you can set snooze duration (in minutes), which is very handy for many people in the morning. The best thing is that you can place an alarm sound so that it rings that ringtone to notify you. It shows a primary user interface to set time. It synchronises with your default time zone, so that you do not mess up the alarm. This is a dedicated website to set the alarm at a specific time. If you want to use the Google website, you need to enter a keyword like this- set timer for 2 minutes. ![]() It is also possible to get the timer in full screen so that you can get a better view of the time. A bell can also ring on the expiry of the timer so that you can know. You can set a timer for 2 minutes, 10 minutes, or anything you want. No matter whether you are in the USA, India, UK, Canada, or anywhere else, you can get the same features irrespective of the region. If you do not need a dedicated time like 7:15 AM or 14:00, you can check out the given timer and stopwatch functionality of Google. Not only a laptop, but mobile users can also set the alarm on these websites. Here are some of the best online alarm clock websites so that you can set the alarm even when you are using the computer. However, if you do not need a dedicated alarm clock and you want to measure some time or do some work like that, you need to take a look at these websites. To wake up in the morning, your mobile’s alarm clock or a dedicated $10 alarm clock is more than enough. Best Online Alarm Clock Websites To Set Alarm ![]() Ires sequences12/12/2023 ![]() ![]() The most straightforward method for coexpression is to use a second promoter within the same vector. How do you link the genes? Allow me to introduce you to three methods for co-expressing multiple genes. To extend your research to protein interaction, you can combine multiple genes and track their function with relation to each other.Īlright, you want a bicistronic plasmid. To advance research on your specific gene, you can add a selection gene or reporter genes. Therefore, transporting your genes together adds a new level of reliability for transfection efficiency.īicistronic plasmids have another distinct advantage: they open the door to a vast array of gene combinations. On the contrary, cotransfection does not have such a guarantee, and you may encounter cells with only one of your genes. The vector transports the genes together into the cells, which means that every cell with one gene also has the other. Introducing the bicistronic plasmidĪs the name suggests, bicistronic plasmids contain two distinct genes of interest within one vector. We want to investigate the concerted effect of two genes working in conjunction.We want to be able to select clones with our gene of interest.We want to be able to confirm the integration of our gene and watch it in action.Genes are powerful tools for directing cell activity, but thanks to that curiosity characteristic of scientists, we want to know more: Excitedly, you throw your gene into the cells and voila! It’s there. doi: 10.1261/’s say you work with a gene, and it has wonderful potential. Structural organization of a viral IRES depends on the integrity of the GNRA motif. A preformed compact ribosome-binding domain in the cricket paralysis-like virus IRES RNAs. ![]() Structural RNA has lower folding energy than random RNA of the same dinucleotide frequency. Xgboost: A scalable tree boosting system.Ĭlote P, Ferre F, Kranakis E, Krizanc D. Proceedings of the 22nd acm sigkdd international conference on knowledge discovery and data mining. doi: 10.1093/bioinformatics/bth374.Ĭhen T, Guestrin C. ![]() Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences. It provides a publicly available tool for all IRES researchers, and can be used in other genomics applications such as gene annotation and analysis of differential gene expression.īioinformatics Internal ribosome entry site (IRES) Machine learning XGBoost.īonnet E, Wuyts J, Rouzé P, Van de Peer Y. IRESpy is a fast, reliable, high-throughput IRES online prediction tool. The trained XGBoost model has been implemented as a bioinformatics tool for IRES prediction, IRESpy (), which has been applied to scan the human 5' UTR and find novel IRES segments. The contributions of model features are well explained by LIME and SHapley Additive exPlanations. The number of features in the model has been greatly reduced, compared to previous predictors, by including global kmer and structural features. The XGBoost model performs better than previous classifiers, with higher accuracy and much shorter computational time. They are incorporated into an IRES classifier based on XGBoost. Sequence features such as kmer words, structural features such as Q MFE, and sequence/structure hybrid features are evaluated as possible discriminators. This paper systematically examines the features that can distinguish IRES from non-IRES sequences. Bioinformatics tools have been developed, but there is no reliable online tool. However, a limited number of confirmed IRES have been reported due to the requirement for highly labor intensive, slow, and low efficiency laboratory experiments. ![]() They have been widely found to play important roles in viral infections and cellular processes. IRES usually function when 5' cap-dependent translation initiation has been blocked or repressed. Internal ribosome entry sites (IRES) are segments of mRNA found in untranslated regions that can recruit the ribosome and initiate translation independently of the 5' cap-dependent translation initiation mechanism. ![]() Windows 11 performance monitor widget12/12/2023 ![]() ![]() Widget Launcher is a Windows Gadget that can be installed and used on both Windows 11/10. Apart from stocks, you can even monitor cryptocurrency pricing using the Watchlist widget. Watchlist is the next best widget for Windows 11 that monitors and showcases the stock values throughout the day.īased on your preference you can customize the widget and choose which stocks appear. At times the widget offers alerts like don’t forget your umbrella during a rainy day. Forecasts offered by the Weather widget are high-quality and super accurate. The interface of the Weather widget is easy to navigate and nicely developed. This widget offers real-time weather condition updates in your area, accompanied by the forecast for the following three days. ![]() The weather widget is one of the most customizable Windows 11 widgets out there. Lastly, Traffic allows users to add multiple destinations. To ensure you get timely updates from the Traffic widgets turn on the location on your Windows 11 laptop or desktop. The widget can come in handy while planning routes to reach your destination. The traffic widget offers detailed information about the traffic condition you will face while you’re on the roads. Lastly, some PC optimization suggestions offered by Tips can even help improve the performance of your PC. If you’re lucky the Tips widget can also recommend you some Windows 11 hidden features. Tips Widget provides brief advice on all things related to Windows 11 and the Microsoft Edge browser. Well, the Tips widget will help you do exactly that. Windows 11 is a fairly new OS and there’s always something new to learn about it. All of the alerts by Entertainment are friendly and informative. This widget will suggest you the best TV shows and movies that you should be watching. Based on your system theme the Calendar Widget can either be dark or light.Īs the name suggests, the Entertainment Widget is all about Entertainment. Outlook Calendar Widget perfectly blends with any background theme and it’s not too obtrusive. The widget clearly showcases the current date as well. Using the Outlook Calendar Widget you can schedule appointments, check upcoming events, or plan your day all at a glance. Calendarįirst, on the list, we have the Windows 11 Calendar Widget. Can You Put Widgets On Desktop Windows 11?īest Windows 11 Widgets And Gadgets 1.How Do I Add A Clock Widget In Windows 11?. ![]() When is xdefiant coming out12/12/2023 ![]() ![]() ![]() They’ll be able to cancel the special abilities of other players, and operate a spider drone to take down enemies remotely. DedSec ( Watch Dogs) – The grassroots hacker group from the Watch Dogs series bring their surprisingly adept gun handling to XDefiant, along with their hacking prowess.Their abilities are all focused around fire, obviously. Cleaners ( Tom Clancy’s The Division) – This enemy faction from The Division pack hazmat suits and flamethrowers, with their specialty being area-of-effect attacks and area denial.So far, Ubisoft has confirmed five different factions for the game, each hailing from a different Ubisoft franchise, and arriving in XDefiant with its own unique style of play. It will also be crossplay, meaning different players using different platforms can match with one another. New seasonal content will land every three months.ĭespite being a more arcade-style game, XDefiant will feature both casual and ranked online multiplayer modes. Now, however, the scope has been widened to games like Watch Dogs and Far Cry, with a promise of regular additions. ![]() When first announced, these factions were limited to those from Tom Clancy’s games, like The Division, Splinter Cell, and Ghost Recon. The X-Factor for XDefiant comes from the idea that each class is born out of a different Ubisoft franchise. The company has described creating distinct styles of shooting gameplay that revolve around weapon types, weapon attachments, character classes, and the various combinations and possibilities that can arise from that. It pits two teams of six players against each other in what Ubisoft describes as a ‘fast-paced arcade shooter’ and a ‘love-letter to fans of classic arena shooters’ – we assume titles like Quake and Unreal Tournament are the touchstones here. XDefiant is a free-to-play online multiplayer first-person shooter. XDefiant enters the free-to-play shooter space in 2023 alongside promising-looking titles like The Finalsand Hyenas. Now, it looks like it’s attempting to capitalise on its expertise and learnings for a more approachable shooter, aimed at a broader audience.īased on initial impressions, it seems to be aiming for a Call of Duty style of game, with a more vibrant art direction, and some character class modifiers to shake things up beyond raw gunplay. The company has already found ongoing success with its considered, competitive tactical shooter Rainbow Six Siege, which it revitalised after a shaky launch in 2015. Nevertheless, the company is making its latest concerted push with XDefiant, an arcade-style shooter that blends different Ubisoft franchises for a fast-paced, class-based FPS. Even developer and publisher giant Ubisoft has tried and failed with new concepts before. A handful of popular behemoths dominate the spare time and disposable incomes of most players, and numerous contenders have come and gone in an attempt to carve out a niche. In 2023, free-to-play gaming is cutthroat. ![]() Bonerdale12/12/2023 ![]() ![]() Additionally, we are using third party session recording technologies that help us better understand our users’ experience, however, the recording data is pseudonymized. These cookies help us to improve our Platform, for example by ensuring that all users are able to find what they are looking for easily. This type of cookies allows us to recognize you when you return to our Platform and to remember, for example, your choice of language.Īnalytics cookies: These cookies allow us to recognize and count the number of users and to see how users use and explore our Platform. These include, for example, cookies that enable a user to log in to our Platform and to check if a user is allowed access to a particular service or content.įunctionality cookies: These cookies help us to personalize and enhance your online experience on our Platform. Strictly necessary cookies: These are cookies that are required for the operation of our Platform. We currently use the following types of cookies, which are set by the Platform’s domains, or by other domains we own or control: We use cookies, which are small text files that are stored in your web browser or downloaded to your device when you visit a Platform. ![]() Cookies and Automatic Data Collection TechnologiesĪs you navigate through and interact with our Platform, we use automatic data collection technologies, if available in your jurisdiction, to collect Platform activity data. ![]() Stacey abrams on growing up poor12/12/2023 ![]() Many Black voters in Georgia say they were motivated to vote in person by Abrams’ gubernatorial fight against Kemp two years ago. The result has been at least 1 million new voters registering in Georgia since 2016, helping to solidify Biden’s unprecedented lead in the state during last week’s presidential election. Because our combined power shows that progress is not only possible, it is inevitable.”įair Fight joined a growing number of grassroots organizations that were united in their purpose to pump up voter registration across the state and get them to the polls on election day. “We changed not only the trajectory of Georgia, we changed the trajectory of the nation. ![]() “Voter suppression happens anywhere,” Abrams said on Tuesday, according to CBS News. Abrams led that charge, launching an organization called Fair Fight that was designed to train voter protection teams in states across the country and educate young voters of color on the issues at hand. Kemp defended his 2018 win and argued that he has not improperly purged 340,000 voters from the rolls, claiming that “despite any claim to the contrary, it has never been easier to register to vote in Georgia and actively engage in the electoral process.” The Republican has continually framed Abrams and her supporters as “left wing radicals.”ĭespite Kemp’s denial of any wrongdoing, the controversy shined a spotlight on the red state’s election system and helped shift Democrats’ attention to voter registration, education and turnout in Georgia. Since the decision, nearly 10 percent of polling places in the state were cut, and Black voters were disproportionately affected as they are more likely than White voters to vote in person. ![]() Her concerns had actually begun years before in 2013, when the Supreme Court gutted the Voting Rights Act of 1965 - originally put in place to protect the voting rights of minorities as they registered and headed to the polls. After a narrow loss of fewer than 55,000 votes, Abrams never officially conceded, contesting that Kemp, who was then secretary of state, had been involved in an act of widespread voter suppression. Stacey Abrams first turned heads in 2018 when she ran for a spot in the governor’s mansion in Georgia against her Republican opponent Brian Kemp. The runoff elections in Georgia may be the single deciding factor on whether or not Republicans maintain a majority in the Senate, and they are fighting hard.Abrams has already raised $6 million for the upcoming Georgia Senate runoff elections in January. ![]() AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |